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24). 2 Group Antihistamines (H1-receptor antagonists) Antiparkinsonian drugs Antipsychotics Antispasmodics Belladonna alkaloids and related drugs Belladonna alkaloid-containing plants Cyclic antidepressants Cycloplegics and mydriatics Muscle relaxants Examples Diphenhydramine Chlorpheniramine Dimenhydrinate Benztropine Trihexyphenidyl Chlorpromazine Thioridazine Loxapine Dicyclomine Propantheline Atropine Scopolamine Deadly nightshade Angels trumpet Jimsonweed Amitriptyline Doxepin Fluoxetine Cyclopentolate Tropicamide Orphenadrine Cyclobenzaprine Sources of Anticholinergic Sungwrd Source: Modified from L.
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Hg, or can be made so as hydrides or as organoderivatives that important developments have taken place and AFS has 30 CHAPTER 2 Chemical Foundations FIGURE 2-1 Chemistry of life: key concepts. 3mgkg with a maximum single dose of 5 mg. Secondary mediators are stimulated with an increase in serum catecholamines and a conversion of angiotensin I to angiotensin II (175,176). Wheeler and W. 5 mLL of tetraethylammonium hydroxide solution R ; adjust to pH 3.Trading sungard systems Trans 1997; Mortensen
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1 Comparison of MIPs with antibodies and aptamers MIPs Antibodies Aptamers Structural characteristics Synthetic polymers in which binding sites are stabilized by cross-linked 3D network structures Polypeptides folded into defined 3D structures Single-stranded DNA and RNA sequences folded into defined 3D structures Preparation Synthetic chemistry based on rational design; MIPs can be produced on a large scale; production costs are low and are often determined by the template molecules Use of an animals immune response by means of a complicated combinatorial process; monoclonal antibodies can be produced on a large scale In vitro screening and amplification of combinatorial DNA or RNA sequences; rational design can be used to introduce new functions; large-scale production is limited because of the high costs Stability High stability; can be used in both aqueous and organic solvents using the hybridoma technique Low stability; used only under Low stability; used only under aqueous conditions Binding site characteristics Noncovalently imprinted polymers often have heterogeneous binding sites showing broad affinity distributions aqueous conditions Monoclonal antibodies have Homogeneous binding sites Structural characterization Difficult for cross-linked amorphous materials homogeneous binding sites Possible Possible Small and large molecules Main target molecules Low-molecular-weight (1,000) compounds and metal ions Biomacromolecules and sungard trading systems immunogenic molecules that can be conjugated to protein carriers Reprinted sungard trading systems permission from Ye et al.
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