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The equivalent damage cycles are 3,f n4,eq14N4,f12D1þ2þ3(NrefN4,f)0:414106(0:01322)(103106)0:4 14761,128 The accumulated damage for additional n4 14 104 cycles is calculated: n4,eq þ n412N4,f Nref 0:4 761128 þ 10000121061030:4 D1þ2þ3þ4 14 N 14 106 14 0:01626 4,f This completes the calculation of the total damage accumulation for the four-level step loading. The sins of the fathers and mothers: Genomic imprinting in mammalian devel- opment.

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