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Recall that some an- tidepressants are inhibitors of CYP450 2D6 and thus can raise the levels of these ACTH CHAPTER 28 Pharmacology of the Adrenal Cortex 491 Feedback inhibition Anterior pituitary gland Adrenal gland Aminoglutethimide Ketoconazole (high) Cholesterol Pregnenolone 17 17-hydroxypregnenolone Trilostane 17-hydroxyprogesterone 21 11-deoxycortisol Trilostane Progesterone 21 11-deoxycorticosterone Metyrapone 11 Corticosterone Aldosterone Ketoconazole 17 Dehydroepiandrosterone Trilostane Androstenedione Metyrapone 11 Cortisol Testosterone Sex steroids FIGURE28-2.

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